Revolutionizing Capsule Technology: Precision Targeting for Advanced Payloads

Capsules for Tomorrow: Enhancing Precision Targeting and Tloring to Advanced Payloads

Abstract:

Vincent Jannin, the Director of RD and Head of Lonza's Capsule Application Lab Services, explores the pivotal role of precision targeting in capsules, particularly beyond their conventional use as simple contners for active pharmaceutical ingredients APIs. Traditionally confined to delivering medications into the stomach via oral administration, standard capsules exhibit limitations when it comes to transporting drugs further down the gastrointestinal tract due to rapid dissolution and immediate release within the acidic environment. To address these constrnts, the industry has innovated with complex multistep processes designed to create delayed-release solid oral dosage forms capable of surviving the stomach's harsh conditions before reaching their targeted destination.

Notwithstanding these advancements, the development process still faces a multitude of bottlenecks that impact the entire capsule manufacturing sector. Challenges such as formulating APIs resistant to demanding processing conditions during both development and production are common pitfalls. While seemingly minor issues in product terms, these obstacles represent significant hurdles for the industry's progress.

To tackle this challenge head-on, Lonza has unveiled Capsule Application Lab Services CALS at its Colmar facility, a specialized division dedicated to achieving precision targeting through advanced technology that enables the development and delivery of novel payloads.

Body:

The article opens by outlining the historical limitations of capsules as mere vessels for oral medications. It then delves into the complexities involved in crafting capsules capable of surviving the digestive system's acidic and enzymatic challenges before reaching their inted site of action in the body.

In a subsequent section, Vincent Jannin highlights the advancements made through multistep processes med at producing delayed-release solid dosage forms that are resilient to the stomach environment, thus ensuring drugs reach their designated location after traversing gastrointestinal barriers.

Next, attention shifts towards the industry's ongoing struggle with developing APIs capable of uring rigorous processing conditions without losing efficacy or safety. The author elucidates how this issue not only poses a challenge for product development but also holds back the broader evolution of capsule technology.

To address these concerns head-on, Lonza introduces Capsule Application Lab Services CALS at its Colmar site. This dedicated division is equipped with cutting-edge facilities and expertise med at solving complex challenges in precision targeting and adapting capsules to deliver advanced payloads effectively and safely.

Concluding Thoughts:

The article concludes by emphasizing the significance of harnessing advancements like CALS and its potential to revolutionize capsule delivery, offering a brighter future for healthcare through innovative solutions that improve patient outcomes. It underscores the need for the industry as a whole to embrace these opportunities and fully realize the benefits of such transformative technologies.

1. Z. Vinarov et al., Current Challenges and Future Perspectives in Oral Absorption Research: An Opinion of the UNGAP Network, Advanced Drug Delivery Reviews 171 2021, pp. 289-331.

2. A. Rump et al., In Vivo Evaluation of a Gastro-Resistant HPMC-Based 'Next Generation Enteric' Capsule, Pharmaceutics 14, no. 16 2022.

3. M. Grimm et al., In Vivo Evaluation of a Gastro-Resistant Enprotect Capsule Under Postprandial Conditions, Pharmaceutics 15, no. 12 2023.

4. V. Jannin et al., In Vitro Evaluation of the Gastrointestinal Delivery of Acid-Sensitive Pancrelipase in a Next Generation Enteric Capsule Using an Exocrine Pancreatic Insufficiency Disease Model, International Journal of Pharmaceutics 630 2022.

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