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Oxyphenbutazone
General Information
This section is not localized to Singapore; please refer to the local prescribing information.
Generic Medicine Information
Contrndications
Blood disorders, such as anemia and thrombocytopenia; peptic ulcer disease; inflammatory bowel diseases like Crohn's or Ulcerative colitis; cardiovascular, pulmonary conditions including asthma or heart disease, or thyroid issues; severe hepatic imprment with elevated liver enzymes over 5 times the upper limit of normal ULN, and renal dysfunction marked by creatinine clearance below 30 mlmin within the last week. Additionally, those suffering from porphyria should avoid use due to potential exacerbation. Furthermore, women who are breastfeeding are advised agnst using this medication.
Special Precautions
Regular monitoring for blood cell counts is recommed. Patients with hepatic or renal dysfunction require careful follow-up of their liver and kidney function tests. Elderly patients need special consideration when administering Oxyphenbutazone due to age-related changes in drug metabolism and pharmacodynamics, which can alter drug clearance and potency. Hypertensive patients should monitor blood pressure levels closely while on treatment. Infections are also a concern, as antibiotics used for treatment might interact with this medication.
Adverse Reactions
Common gastrointestinal issues such as diarrhea, dyspepsia indigestion, nausea or vomiting may occur due to the drug's action on the digestive system. Serious complications like GI bleeding and ulcers need prompt medical attention. Patients should report any signs of rash immediately. Hepatic dysfunction might manifest with symptoms such as jaundice or elevated liver enzymes which require immediate physician consultation.
Serious adverse reactions include hypersensitivity reactions like anaphylaxis, skin rashes that could be severe, including Stevens-Johnson syndrome and toxic epidermal necrolysis TEN. Nephrotoxicity leading to acute kidney injury might occur if adequate hydration is not mntned. Photosensitivity or increased sensitivity to sunlight can lead to sunburns; patients should take appropriate precautions when exposed to sunlight.
Potentially Fatal Adverse Effects
Oxyphenbutazone has been associated with severe myelosuppression, a condition that causes a reduction in all blood cell counts leading to anemia and leukopenia. In rare instances, it can cause aplastic anaemia where bone marrow stops producing new blood cells which is potentially life-threatening.
Drug Interactions
This medication could diminish the effectiveness of ACE inhibitors, beta-blockers, or diuretics by interfering with their absorption in the gut. It might increase the plasma levels of phenytoin and lithium when used together. The absorption rate can be delayed if taken concurrently with tricyclic antidepressants.
Severe interactions are possible when combined with oral anticoagulants, hydantoins or other medications that manage diabetes through insulin or oral hypoglycaemic agents due to the risk of exacerbating blood thinning effects and hyperglycemia respectively.
Mechanism of Action
Oxyphenbutazone is a derivative of phenylbutazone that functions as a potent anti-inflammatory agent by inhibiting prostaglandin synthesis through COX enzymes. However, given its potential for severe toxicity, it is not recommed for long-term use.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs NSDs
The information presented in has been indepently compiled by MIMS based on Oxyphenbutazone from various sources and serves as a reference. The therapeutic uses, prescribing guidelines, and product avlability may vary between countries. Please consult the specific local product monograph for approved information relevant to your practice area. Though significant effort was made to ensure accuracy, MIMS will not assume responsibility or liability in any clms or damages arising from the use of this information or its content.
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Oxyphenbutazone Contraindications Review Special Precautions for Oxyphenbutazone Use Adverse Reactions Profile of Oxyphenbutazone Drug Interaction with Oxyphenbutazone Explained Oxyphenbutazone Mechanism Action Insight Nonsteroidal Anti Inflammatory Drugs Overview