Yunnan Baiyao: A Traditional Chinese Medicine for Bleeding Disorders in Pets

Yunnan Byao is a herbal remedy that has been used for more than 114 years, initially to stop bleeding from battle injuries. It has also been used recently as a way to decrease blood transfusion needs before surgery and for managing ulcerative gastrointestinal issues in s. While there are limited studies specifically about its use on animals, it is commonly employed by veterinarians.

At Angell Animal Medical Center, we have been utilizing Yunnan Byao topically and orally for several years as an auxiliary tool to prevent bleeding in various cases such as hemoabdomens, pericardial effusions, and epistaxis. This supplement comes in capsule form contning 0.25 grams each or powder form within a bottle of 4 grams.

Typical usage involves administering one capsule 0.25 grams two to three times dly for pets weighing up to 20 pounds.

Ingredients listed on the packaging include the following:

• Iron

• Zinc

• Magnesium

• Manganese

• Cupric oxide

• Sulfur

The primary function of Yunnan Byao is clotting factor synthesis and platelet aggregation. However, recent research has shown that this remedy may also contribute to cell death through caspase-mediated apoptosis when used in certn concentrations on canine hemangiosarcoma cell lines.

In a study conducted by Wirth et al., it was concluded that Yunnan Byao can induce dose- and time-depent apoptosis. The same researchers later found that there were no significant effects on clotting parameters as measured by platelet activation, buccal mucosal bleeding time, prothrombin time, activated partial thromboplastin time, and thromboelastography in healthy dogs when using doses four times higher than usual.

Murphy et al.'s retrospective case-controlled study of 67 dogs found no side effects associated with its use. However, the study did not find a significant difference in survival time compared to control groups.

Despite these findings, the choice to use Yunnan Byao should be based on an individual evaluation by both veterinarian and pet owner considering the specific case circumstances.

References:

Wirth et al., In Vitro Effects of Yunnan Byao on Canine Hemangiosarcoma Cell Lines, Vet Comp Oncol 143:281-94 2014.

Egger et al., The Effect of Yunnan Byao on Platelet Activation, Buccal Mucosal Bleeding Time, Prothrombin Time, Activated Partial Thromboplastin Time, and Thromboelastography in Healthy Dogs: A Randomized Controlled Blinded Study, AJTCVM 112:27-36 2016.

Murphy et al., Use of Yunnan Byao and Epsilon-Aminocaproic Acid in Dogs with Right Atrial Masses and Pericardial Effusion, J Vet Emerg Crit Care, 1-6 2016.

This summary is material and highlights key points about Yunnan Byao's uses, benefits, limitations, and safety. Additional research or professional advice should be sought for more in-depth information.

For any further questions regarding this topic, please reach out to Dr. Whelan at [email protected] or call 617-522-7282.
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